3rd Bio Iberoamérica, 2022 (keynote speech)
3º Bio Iberoamérica – Congresso Ibero-Americano de Biotecnologia, 7-9 abril 2022, Braga (Portugal).
Lucília Domingues. Strategic Yeast Engineering for Sustainable Biorefineries
The astonishing growth of the world population, the global climate changes, and the depletion of fossil fuels are strong drivers for the development of a resource-efficient and sustainable economy. In this regard, the biotechnological manufacturing of lignocellulosic-based biofuels/biochemicals is pivotal. In these processes, fermentation is a core operation and the microorganism used, generally, Saccharomyces cerevisiae, plays a central role. Designing a tailor-made yeast considering the strain background and the particular raw material and process is of major importance and, in this context, industrial S. cerevisiae, presenting robustness traits is a promising platform. Following a process-oriented yeast design, the successful engineering of xylose metabolism, inhibitors tolerance or cell-surface display of hydrolytic enzymes, resulting in ethanol-producing competitive processes have been attained. Nevertheless, integration with the production of high-value low-volume biochemicals can further improve economic feasibility. The design of yeast to produce value-added compounds like xylitol or arabitol, resveratrol or to be used as whole-cell biocatalysts for bioconversion of highly versatile compounds present in lignocellulose like valuable furan-derivatives could also be demonstrated. Overall, our results show that a rational yeast design based on the strain metabolic background under a process integration framework is a potential strategy for biorefineries sustainable development.
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